Description

4-[(6-Bromo-Pyridin-2-Ylamino)-Methyl]-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity (98+%) advanced pharmaceutical intermediate with the molecular formula C16H24BrN3O2 and a molecular weight of 370.29. This compound is a critical building block in modern medicinal chemistry, valued for its piperidine and bromopyridine moieties which are essential for constructing bioactive molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• CNS Drug Development: Used in the research and development of therapeutics targeting neurological disorders, leveraging the piperidine core.
• Kinase Inhibitor Synthesis: The bromopyridine group makes it a valuable precursor for synthesizing potential kinase inhibitors for oncology applications.
• Chemical Biology Probes: Employed in the creation of labeled or tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Item	Details
Product Name	4-[(6-Bromo-Pyridin-2-Ylamino)-Methyl]-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1065484-37-8
Molecular Formula	C16H24BrN3O2
Molecular Weight	370.29 g/mol
Synonyms	tert-Butyl 4-[[(6-bromopyridin-2-yl)amino]methyl]piperidine-1-carboxylate; 1-Boc-4-[(6-bromo-2-pyridinylamino)methyl]piperidine; 1-(tert-Butoxycarbonyl)-4-[[(6-bromo-2-pyridinyl)amino]methyl]piperidine; 4-[(6-Bromo-2-pyridinylamino)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; BOC-Piperidine-4-[(6-bromo-pyridin-2-ylamino)-methyl]; 1065484-37-8; (6-Bromo-pyridin-2-yl)-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]amine
EINECS	Contact for details

Quality Control

Our 4-[(6-Bromo-Pyridin-2-Ylamino)-Methyl]-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the specified 98+% purity and identity criteria. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.