Description

4-(4-Fluoro-Benzoyloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core and fluorinated benzoyloxy protecting group. This compound is essential for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system and other therapeutic areas. It is a critical building block for pharmaceutical manufacturers and contract research organizations (CROs) engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, especially those containing a piperidine moiety.
• Medicinal Chemistry Research: Used in the discovery and optimization of new chemical entities (NCEs) for various therapeutic targets.
• Process Chemistry Development: Serves as a standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Protecting Group Chemistry: The tert-butyloxycarbonyl (Boc) group provides a versatile protecting strategy for amines in multi-step organic synthesis.
• Fluorinated Compound Synthesis: The 4-fluorobenzoyl moiety introduces fluorine atoms, a common strategy in drug design to improve metabolic stability and bioavailability.

Basic Information

Product Name	4-(4-Fluoro-Benzoyloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1065484-34-5
Molecular Formula	C17H22FNO4
Molecular Weight	323.37 g/mol
Synonyms	1-Boc-4-(4-fluorobenzoyloxy)piperidine; tert-Butyl 4-[(4-fluorobenzoyl)oxy]piperidine-1-carboxylate; 4-(4-Fluorobenzoyloxy)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(4-fluorobenzoyloxy)piperidine; N-Boc-4-(4-fluorobenzoyloxy)piperidine; Piperidine-1-carboxylic acid, 4-[(4-fluorobenzoyl)oxy]-, 1,1-dimethylethyl ester; 1065484-34-5
EINECS	Contact for details

Quality Control

Our 4-(4-Fluoro-Benzoyloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure a purity of 98+%. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry-standard analytical methods, including HPLC, GC, NMR, and mass spectrometry, to guarantee product integrity and consistency for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.