Description

4-(3-Cyano-Pyridin-2-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity (98+%) advanced pharmaceutical intermediate with the molecular formula C16H21N3O3 and a molecular weight of 303.36. This compound is a critical building block in modern medicinal chemistry, valued for its piperidine and cyano-pyridine motifs which are essential for constructing bioactive molecules. It is primarily sought by R&D and process chemistry teams in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Process Development: Serves as a starting material or intermediate in scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Library Synthesis: Employed in combinatorial chemistry to generate diverse compound libraries for high-throughput screening (HTS).
• Chemical Biology Probes: Used to develop tool compounds and probes for investigating biological pathways and target validation.

Basic Information

Product Name	4-(3-Cyano-Pyridin-2-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1065484-09-4
Molecular Formula	C16H21N3O3
Molecular Weight	303.36 g/mol
Synonyms	tert-Butyl 4-[(3-cyanopyridin-2-yl)oxy]piperidine-1-carboxylate; 1-Boc-4-[(3-cyano-2-pyridyl)oxy]piperidine; 4-(3-Cyano-2-pyridyloxy)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[(3-cyano-2-pyridinyl)oxy]piperidine; 4-(3-Cyanopyridin-2-yloxy)piperidine-1-carboxylic acid tert-butyl ester; 2-[(1-Boc-4-piperidinyl)oxy]-3-cyanopyridine; 1065484-09-4
EINECS	Contact for details

Quality Control

Our 4-(3-Cyano-Pyridin-2-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure a purity of 98+% and confirm identity and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.