Description

3-(3-Nitro-Pyridin-2-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine and nitro-pyridine functional groups. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system and other therapeutic areas. It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those with piperidine-based pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Process Development: Serves as a critical starting material or intermediate in scaling up API synthesis under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology: Utilized in the development of chemical probes and tool compounds for target validation and biological pathway studies.
• Agrochemical Research: Potential intermediate in the development of novel crop protection agents and pesticides.

Basic Information

Product Name	3-(3-Nitro-Pyridin-2-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1065484-07-2
Molecular Formula	C15H21N3O5
Molecular Weight	323.35 g/mol
Synonyms	1-Boc-3-[(3-nitropyridin-2-yl)oxy]piperidine; tert-Butyl 3-[(3-nitropyridin-2-yl)oxy]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-[(3-nitropyridin-2-yl)oxy]piperidine; 3-(3-Nitro-2-pyridyloxy)piperidine-1-carboxylic acid tert-butyl ester; 2-[(1-Boc-3-piperidinyl)oxy]-3-nitropyridine; BOC-3-(3-Nitro-pyridin-2-yloxy)-piperidine; 1065484-07-2; 3-(3-Nitro-2-pyridinyloxy)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 98+% grade product undergoes rigorous analytical testing to ensure it meets the stringent requirements for pharmaceutical R&D. Quality is verified by multiple orthogonal methods including HPLC for purity and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity, and impurity profiles. Our quality management system supports development under ISO guidelines, and we can supply material suitable for use in GLP and cGMP development workflows upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.