Description

(2E)-3-(5-Bromo-2-Fluorophenyl)-2-Propenoic Acid, Methyl Ester is a high-purity, synthetic organic intermediate characterized by its bromo-fluorophenyl and α,β-unsaturated ester functional groups. This compound is critical for enabling precise chemical synthesis in advanced research and development, offering a versatile building block for constructing complex molecular architectures. It is primarily sought after by pharmaceutical, agrochemical, and advanced material scientists for applications in drug discovery, ligand synthesis, and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and oncological pathways.
• Agrochemical Synthesis: Serves as a precursor in the creation of advanced herbicides, fungicides, and insecticides, leveraging the halogenated aromatic system for bioactivity.
• Ligand and Catalyst Development: Used in organometallic chemistry and catalysis research to develop new ligands for transition metal complexes.
• Material Science Research: Employed as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular processes.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the fine chemical industry.

Basic Information

Product Name	(2E)-3-(5-Bromo-2-Fluorophenyl)-2-Propenoic Acid, Methyl Ester
CAS No.	1065168-05-9
Molecular Formula	C10H8BrFO2
Molecular Weight	259.07 g/mol
Synonyms	Methyl (2E)-3-(5-bromo-2-fluorophenyl)acrylate; Methyl (E)-3-(5-Bromo-2-fluorophenyl)propenoate; (E)-Methyl 3-(5-bromo-2-fluorophenyl)acrylate; 5-Bromo-2-fluorocinnamic acid methyl ester; (E)-3-(5-Bromo-2-fluorophenyl)acrylic acid methyl ester; trans-3-(5-Bromo-2-fluorophenyl)-2-propenoic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of (2E)-3-(5-Bromo-2-Fluorophenyl)-2-Propenoic Acid, Methyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical intermediate grade meets rigorous in-house specifications, with purity typically ≥97% (by HPLC). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and physical characteristics.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.