Description

1-Boc-4-((1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl)piperazine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine scaffold linked to a fused heterocyclic system. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of targeted small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and antiviral research.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and synthesizing potent and selective kinase inhibitors due to its privileged heterocyclic structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to improve pharmacokinetic properties.
• Bioconjugation & Probe Synthesis: The Boc-protected amine allows for selective deprotection and further functionalization, useful for creating chemical probes or antibody-drug conjugates (ADC) linkers.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials under GMP-like conditions.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic synthesis and chemical biology.

Basic Information

Item	Detail
Product Name	1-Boc-4-((1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl)piperazine
CAS No.	1065100-86-8
Molecular Formula	C18H24N4O2
Molecular Weight	328.41 g/mol
Synonyms	1-Boc-4-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)piperazine; 1-Boc-4-((7-azaindol-3-yl)methyl)piperazine; tert-Butyl 4-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)piperazine-1-carboxylate; 4-((1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)piperazine; 1065100-86-8; 1-Boc-4-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-((1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl)piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with ICH guidelines for impurities, supporting development from preclinical to commercial stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.