Description

tert-Butyl 2-(Dimethylamino)-4-(p-Tolylsulfonyloxy)-7,8-Dihydropyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate is a high-value, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for the synthesis of targeted therapeutic agents, offering a key building block for medicinal chemistry research and development. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel drug candidates, particularly in oncology and kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of kinase inhibitors and other targeted small-molecule therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug discovery projects.
• Process Chemistry Development: Serves as a critical intermediate for scaling up the synthesis of active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	tert-Butyl 2-(Dimethylamino)-4-(p-Tolylsulfonyloxy)-7,8-Dihydropyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate
CAS No.	1065075-79-7
Molecular Formula	C25H32N4O5S
Molecular Weight	500.61 g/mol
Synonyms	tert-Butyl 2-(dimethylamino)-4-[(4-methylphenyl)sulfonyl]oxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate; 6-tert-Butoxycarbonyl-2-(dimethylamino)-4-(p-toluenesulfonyloxy)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; 1065075-79-7; 2-(Dimethylamino)-4-(p-tolylsulfonyloxy)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development projects with material produced under GMP-compatible conditions and can provide regulatory starting material documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.