Description

3-Bromo-5-Nitro-2-(Piperidin-1-Yl)Pyridine is a high-value, multi-functional heterocyclic building block characterized by its bromo and nitro substituents on a pyridine core. This compound is essential for facilitating complex molecular transformations in advanced synthetic chemistry, offering a strategic handle for cross-coupling and nucleophilic substitution reactions. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its functional groups for structure-activity relationship (SAR) studies.
• Material Science: Acts as a building block for creating functionalized ligands in coordination chemistry and for developing advanced organic electronic materials.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl and amine-linked structures.
• Nucleophilic Aromatic Substitution: The nitro group activates the pyridine ring for substitution, allowing for the introduction of various nucleophiles.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	3-Bromo-5-Nitro-2-(Piperidin-1-Yl)Pyridine
CAS No.	1065074-87-4
Molecular Formula	C10H12BrN3O2
Molecular Weight	286.13 g/mol
Synonyms	2-(Piperidin-1-yl)-3-bromo-5-nitropyridine; 3-Bromo-5-nitro-2-piperidin-1-ylpyridine; 3-Bromo-5-nitro-2-(1-piperidinyl)pyridine; Pyridine, 3-bromo-5-nitro-2-(1-piperidinyl)-; 1065074-87-4; 3-Bromo-5-nitro-2-piperidinopyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Nitro-2-(Piperidin-1-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (HPLC), related substances, and residual solvents. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.