Description

3-(7-Nitro-1-Oxo-2,3-Dihydro-1H-Isoindol-2-Yl)Piperidine-2,6-Dione is a high-purity, specialized organic compound with the CAS registry number 1063995-54-9. This compound is of significant interest as a key synthetic intermediate and building block in advanced pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other complex molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly in oncology and immunology research.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the design and construction of heterobifunctional molecules for targeted protein degradation.
• Chemical Biology Research: Employed as a molecular probe or linker in studying protein-protein interactions and cellular pathways.
• Medicinal Chemistry: Acts as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale manufacturing of complex APIs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	3-(7-Nitro-1-Oxo-2,3-Dihydro-1H-Isoindol-2-Yl)Piperidine-2,6-Dione
CAS No.	1063995-54-9
Molecular Formula	C13H11N3O5
Molecular Weight	289.25 g/mol
Synonyms	2,6-Dioxopiperidin-3-yl 7-nitro-1-oxo-2,3-dihydro-1H-isoindole-2-carboxylate; 3-(7-Nitro-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione; 7-Nitro-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Lenalidomide nitro analog; Nitro-substituted thalidomide derivative
EINECS	Contact for details

Quality Control

Our 3-(7-Nitro-1-Oxo-2,3-Dihydro-1H-Isoindol-2-Yl)Piperidine-2,6-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.