Description

tert-Butyl 6-(Hydroxymethyl)-1,4-Oxazepane-4-Carboxylate is a high-value, protected heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it provides a versatile chiral scaffold with orthogonal protecting groups, enabling the efficient construction of complex molecules with precise stereochemistry. Pharmaceutical research and development teams need it for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) agents and other therapeutic modalities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for neurological and psychiatric disorders.
• Peptidomimetic Chemistry: Serves as a constrained, non-natural amino acid analog for designing bioactive peptides with enhanced metabolic stability and receptor selectivity.
• Medicinal Chemistry Scaffold: Used to explore structure-activity relationships (SAR) by introducing diverse functional groups at the hydroxymethyl and carboxylate positions.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective transformations to create enantiomerically pure compounds.
• Chemical Biology Probe Development: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical building block supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.

Basic Information

Product Name	tert-Butyl 6-(Hydroxymethyl)-1,4-Oxazepane-4-Carboxylate
CAS No.	1063734-19-9
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	4-tert-Butoxycarbonyl-6-(hydroxymethyl)-1,4-oxazepane; 1,4-Oxazepane-4-carboxylic acid, 6-(hydroxymethyl)-, 1,1-dimethylethyl ester; 6-(Hydroxymethyl)-1,4-oxazepane-4-carboxylic acid tert-butyl ester; Boc-6-(hydroxymethyl)-1,4-oxazepane; tert-Butyl 6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate; 1,4-Oxazepane, 6-(hydroxymethyl)-, 4-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-(Hydroxymethyl)-1,4-Oxazepane-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.