Description

tert-Butyl 8-Methyl-1,3,4,5-Tetrahydro-2H-Pyrido[4,3-B]Indole-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern organic synthesis. This compound serves as a critical building block in the development of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system disorders. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of novel therapeutic agents.

Application

• Key Intermediate in API Synthesis: Primarily used in the multi-step synthesis of complex pharmaceutical compounds, especially those with indole or tetrahydro-β-carboline scaffolds.
• Neurological & Psychiatric Drug Research: Serves as a precursor in the development of potential therapeutics for conditions such as depression, anxiety, and neurodegenerative diseases.
• Medicinal Chemistry & Lead Optimization: Employed by research chemists for structure-activity relationship (SAR) studies and the modification of lead compounds to enhance efficacy and reduce side effects.
• Process Chemistry & Scale-Up: Used in process development for optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing.
• Academic Research: Utilized in universities and research institutes for studying novel heterocyclic chemistry and developing new synthetic methodologies.
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial drug substances.

Basic Information

Item	Details
Product Name	tert-Butyl 8-Methyl-1,3,4,5-Tetrahydro-2H-Pyrido[4,3-B]Indole-2-Carboxylate
CAS No.	1060980-53-1
Molecular Formula	C17H22N2O2
Molecular Weight	286.37 g/mol
Synonyms	2H-Pyrido[4,3-b]indole-2-carboxylic acid, 1,3,4,5-tetrahydro-8-methyl-, 1,1-dimethylethyl ester; tert-Butyl 8-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carboxylate; 8-Methyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester; tert-Butyl 8-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indole-2-carboxylate (alternative numbering); 1060980-53-1
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Methyl-1,3,4,5-Tetrahydro-2H-Pyrido[4,3-B]Indole-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.