Description

1-(6-Chloropyridin-2-Yl)-2,2,2-Trifluoroethanone is a high-value trifluoromethyl ketone derivative and a key fluorinated pyridine building block. This compound is essential for introducing the trifluoroacetyl pharmacophore into target molecules, significantly altering their physicochemical and biological properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for developing active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for synthesizing specialized ligands, catalysts, and fluorinated polymers with unique electronic and surface properties.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme mechanisms and protein function.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis services catering to R&D and scale-up projects requiring fluorinated heterocycles.

Basic Information

Product Name	1-(6-Chloropyridin-2-Yl)-2,2,2-Trifluoroethanone
CAS No.	1060811-90-6
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	2,2,2-Trifluoro-1-(6-chloro-2-pyridinyl)ethanone; 1-(6-Chloro-2-pyridinyl)-2,2,2-trifluoroethanone; 6-Chloro-2-(trifluoroacetyl)pyridine; 2-Acetyl-6-chloropyridine, 2,2,2-trifluoro-; 2,2,2-Trifluoro-1-(6-chloropyridin-2-yl)ethan-1-one; (6-Chloropyridin-2-yl)(trifluoromethyl)methanone; TFAP-CP
EINECS	Contact for details

Quality Control

Our 1-(6-Chloropyridin-2-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.