Description

1-(6-(Trifluoromethyl)Pyridin-3-Yl)Cyclopropane-1-Carboxylic Acid is a high-value, multifunctional organic building block featuring a cyclopropane carboxylic acid group attached to a trifluoromethyl-substituted pyridine ring. This compound matters for its unique structural motifs, which are critical for modulating the physicochemical and biological properties of advanced molecules in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for applications such as medicinal chemistry, where it serves as a key intermediate in the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the trifluoromethyl and pyridine groups can enhance biological activity and environmental stability.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and material science due to its rigid cyclopropane structure and coordinating pyridine nitrogen.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Advanced Material Development: Acts as a monomer or functionalizing agent in the creation of specialty polymers and organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	1-(6-(Trifluoromethyl)Pyridin-3-Yl)Cyclopropane-1-Carboxylic Acid
CAS No.	1060811-01-9
Molecular Formula	C10H8F3NO2
Molecular Weight	231.17 g/mol
Synonyms	1-[6-(Trifluoromethyl)-3-pyridinyl]cyclopropanecarboxylic acid; 1-(6-(Trifluoromethyl)pyridin-3-yl)cyclopropanecarboxylic acid; 1-(6-(Trifluoromethyl)-3-pyridyl)cyclopropane-1-carboxylic acid; Cyclopropanecarboxylic acid, 1-[6-(trifluoromethyl)-3-pyridinyl]-; 1060811-01-9; 1-(6-Trifluoromethylpyridin-3-yl)cyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-(6-(Trifluoromethyl)Pyridin-3-Yl)Cyclopropane-1-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for use under cGMP guidelines for advanced pharmaceutical intermediates upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤3.0% Any single impurity ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.