Description

4-Hydroxy-6-Trifluoromethyl-Nicotinic Acid is a high-value trifluoromethylated pyridine derivative, a crucial building block in modern synthetic chemistry. Its unique structure, combining a nicotinic acid core with hydroxy and trifluoromethyl substituents, makes it indispensable for creating novel compounds with enhanced biological activity and physicochemical properties. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting enzymes and receptors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials and advanced polymers.
• Chemical Biology Probes: Utilized to build molecular probes for studying biological processes and target identification.
• Custom Synthesis and Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke synthesis services.

Basic Information

Product Name	4-Hydroxy-6-Trifluoromethyl-Nicotinic Acid
CAS No.	1060810-79-8
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	6-(Trifluoromethyl)-4-hydroxynicotinic acid; 4-Hydroxy-6-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 4-hydroxy-6-(trifluoromethyl)-; 4-Hydroxy-6-trifluoromethylnicotinic acid; 4-Hydroxy-6-trifluoromethyl-3-pyridinecarboxylic acid; 1060810-79-8; 4-Hydroxy-6-(trifluoromethyl)nicotinic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxy-6-Trifluoromethyl-Nicotinic Acid is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.