Description

Methyl 2-Hydroxy-6-(Trifluoromethyl)Isonicotinate is a high-value, multi-functional heterocyclic building block featuring a trifluoromethyl group and a methyl ester. This compound is critical for introducing the trifluoromethyl moiety, which enhances metabolic stability, lipophilicity, and bioavailability in target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty chemicals, liquid crystals, and functional polymers requiring fluorinated aromatic systems.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes, enzyme inhibitors, and labeled compounds for biological studies.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	Methyl 2-Hydroxy-6-(Trifluoromethyl)Isonicotinate
CAS No.	1060810-77-6
Molecular Formula	C8H6F3NO3
Molecular Weight	221.13 g/mol
Synonyms	2-Hydroxy-6-(trifluoromethyl)isonicotinic acid methyl ester; Methyl 2-hydroxy-6-(trifluoromethyl)pyridine-4-carboxylate; 6-(Trifluoromethyl)-2-hydroxypyridine-4-carboxylic acid methyl ester; 4-Pyridinecarboxylic acid, 2-hydroxy-6-(trifluoromethyl)-, methyl ester; Methyl 2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-4-carboxylate (tautomeric form)
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Hydroxy-6-(Trifluoromethyl)Isonicotinate adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.