Description

4-Bromo-6-(Trifluoromethyl)Picolinic Acid is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for facilitating rapid structural diversification in medicinal chemistry and agrochemical research, offering a unique combination of reactivity and physicochemical property modulation. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and crop protection industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-inflammatory drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers and advanced materials.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry and for the synthesis of molecular tools.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex molecular architectures.

Basic Information

Product Name	4-Bromo-6-(Trifluoromethyl)Picolinic Acid
CAS No.	1060810-68-5
Molecular Formula	C7H3BrF3NO2
Molecular Weight	269.99 g/mol
Synonyms	4-Bromo-6-(trifluoromethyl)pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 4-bromo-6-(trifluoromethyl)-; 4-Bromo-6-trifluoromethylpicolinic acid; 4-Bromo-6-(trifluoromethyl)-2-pyridinecarboxylic acid; 4-Bromo-6-(trifluoromethyl)picolinate
EINECS	Contact for details

Quality Control

Our 4-Bromo-6-(Trifluoromethyl)Picolinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from strong light sources. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.