Description

2-Chloro-5-Hydroxyisonicotinaldehyde is a high-purity, multi-functional heterocyclic aldehyde building block of significant interest in advanced organic synthesis. Its unique molecular structure, featuring both chloro and hydroxy substituents on the pyridine ring, makes it a versatile intermediate for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, metal-organic frameworks (MOFs), and functional polymers.
• Chemical Biology Probes: Utilized to build molecular probes and tags for studying biological processes and enzyme mechanisms.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Chloro-5-Hydroxyisonicotinaldehyde
CAS No.	1060804-53-6
Molecular Formula	C6H4ClNO2
Molecular Weight	157.55 g/mol
Synonyms	5-Hydroxy-2-chloroisonicotinaldehyde; 2-Chloro-5-hydroxypyridine-4-carbaldehyde; 4-Pyridinecarboxaldehyde, 2-chloro-5-hydroxy-; Isonicotinaldehyde, 2-chloro-5-hydroxy-; 2-Chloro-5-hydroxypyridine-4-carboxaldehyde; 2-Chloro-5-hydroxy-4-formylpyridine; 4-Formyl-2-chloro-5-hydroxypyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Hydroxyisonicotinaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be light-sensitive and hygroscopic; handle and store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.