Description

1-(3-Bromopyridin-4-Yl)-2,2,2-Trifluoroethanone is a high-purity, multi-functional organic building block characterized by its reactive bromopyridine and trifluoroacetyl functional groups. This compound is essential for advanced pharmaceutical and agrochemical research, serving as a key intermediate in the synthesis of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialized ligands, catalysts, and functionalized polymers with unique electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Fluorine Chemistry: A valuable source of the trifluoroacetyl moiety for introducing fluorine atoms into target molecules to modulate their lipophilicity and bioavailability.

Basic Information

Product Name	1-(3-Bromopyridin-4-Yl)-2,2,2-Trifluoroethanone
CAS No.	1060802-29-0
Molecular Formula	C7H3BrF3NO
Molecular Weight	253.00 g/mol
Synonyms	3-Bromo-4-(2,2,2-trifluoroacetyl)pyridine; 4-Acetyl-3-bromopyridine, 2,2,2-trifluoro-; 2,2,2-Trifluoro-1-(3-bromo-4-pyridinyl)ethanone; 1-(3-Bromo-4-pyridinyl)-2,2,2-trifluoroethanone; 3-Bromo-4-pyridyl trifluoromethyl ketone; 4-(Trifluoroacetyl)-3-bromopyridine; 3-Bromo-α,α,α-trifluoro-4-pyridinylmethanone
EINECS	Contact for details

Quality Control

Our 1-(3-Bromopyridin-4-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.