Description

1-(5-Chloropyridin-3-Yl)-2,2,2-Trifluoroethanone is a high-purity trifluoromethyl ketone derivative, serving as a critical advanced intermediate for the synthesis of complex organic molecules. Its value lies in the unique reactivity of the trifluoroacetyl group and the halogenated pyridine scaffold, which are essential for introducing specific pharmacophores and modifying physicochemical properties in target compounds. This product is primarily needed by research and development teams in the pharmaceutical and agrochemical industries, where it is utilized to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, leveraging the pyridine and trifluoromethyl motifs for enhanced bioactivity.
• Material Science Precursor: Serves as a starting material for synthesizing specialized ligands, catalysts, and monomers for advanced polymers.
• Chemical Biology Probe Development: Employed in creating molecular probes and tags to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A vital substrate for fine chemical and custom synthesis organizations serving the life sciences sector.

Basic Information

Product Name	1-(5-Chloropyridin-3-Yl)-2,2,2-Trifluoroethanone
CAS No.	1060802-11-0
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	5-Chloro-3-trifluoroacetylpyridine; 3-Acetyl-5-chloropyridine, 2,2,2-trifluoro-; 1-(5-Chloro-3-pyridinyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-chloropyridin-3-yl)ethanone; 5-Chloro-3-(trifluoroacetyl)pyridine; 3-(Trifluoroacetyl)-5-chloropyridine; 1-(5-Chloro-3-pyridyl)-2,2,2-trifluoroethanone
EINECS	Contact for details

Quality Control

Our 1-(5-Chloropyridin-3-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.