Description

1-(5-Chloro-Pyridin-2-Yl)-2,2,2-Trifluoro-Ethanone is a high-purity trifluoromethyl ketone building block featuring a chloropyridine moiety. This compound is valued for its role as a key synthetic intermediate in the development of advanced agrochemicals and pharmaceuticals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily sought by R&D chemists and process development teams in the fine chemical, crop protection, and pharmaceutical industries for constructing complex molecules.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of novel insecticides, herbicides, and fungicides, leveraging the bioactivity of the chloropyridine and trifluoromethyl groups.
• Pharmaceutical Building Block: Used in medicinal chemistry for the research and development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) and infectious diseases.
• Material Science Research: Serves as a specialty monomer or cross-linking agent in the development of advanced polymers with specific optical or electronic properties.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Synthesis: A versatile reagent for introducing the 2,2,2-trifluoro-1-(pyridinyl)ethanone moiety into more complex molecular architectures.

Basic Information

Product Name	1-(5-Chloro-Pyridin-2-Yl)-2,2,2-Trifluoro-Ethanone
CAS No.	1060802-09-6
Molecular Formula	C8H3ClF3NO
Molecular Weight	209.56 g/mol
Synonyms	2-Acetyl-5-chloropyridine trifluoromethyl ketone; 5-Chloro-2-(2,2,2-trifluoroacetyl)pyridine; 1-(5-Chloro-2-pyridinyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-chloro-2-pyridinyl)ethanone; 5-Chloro-2-pyridyl trifluoromethyl ketone; TFAP-CP (common abbreviation)
EINECS	Contact for details

Quality Control

Our 1-(5-Chloro-Pyridin-2-Yl)-2,2,2-Trifluoro-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.