Description

4-Bromo-3-(trifluoromethyl)pyridine is a high-purity, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and a trifluoromethyl group on the pyridine ring, makes it an exceptionally versatile intermediate for introducing these valuable motifs into target molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to create novel compounds with enhanced biological activity or specific physical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group often improves efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require halogenated aromatic components.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological systems and drug-target interactions.

Basic Information

Product Name	4-Bromo-3-(trifluoromethyl)pyridine
CAS No.	1060801-89-9
Molecular Formula	C6H3BrF3N
Molecular Weight	225.99 g/mol
Synonyms	3-(Trifluoromethyl)-4-bromopyridine; 4-Bromo-3-trifluoromethylpyridine; 4-Bromo-α,α,α-trifluoro-3-picoline; Pyridine, 4-bromo-3-(trifluoromethyl)-; 1060801-89-9
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-(trifluoromethyl)pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.