Description

2-Cyanopyridine-3-Sulfonyl Chloride is a versatile and highly reactive chemical intermediate, primarily valued for its role as a key building block in advanced organic synthesis. Its core value proposition lies in enabling the efficient introduction of the sulfonyl chloride functional group into complex molecular architectures, which is critical for developing active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create novel sulfonamide derivatives and other high-value compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel sulfonamide-based drug candidates, including kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that incorporate sulfonyl functional groups for enhanced activity.
• Functional Material Development: Serves as a building block for creating advanced polymers, liquid crystals, and organic electronic materials with specific sulfonated properties.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling proteins or modifying biomolecules in research applications.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Industrial R&D: Fundamental reagent for methodological development and exploring new chemical reactions in heterocyclic and medicinal chemistry.

Basic Information

Product Name	2-Cyanopyridine-3-Sulfonyl Chloride
CAS No.	1060801-06-0
Molecular Formula	C6H3ClN2O2S
Molecular Weight	202.62 g/mol
Synonyms	3-Pyridinesulfonyl chloride, 2-cyano-; 2-Cyano-3-pyridinesulfonyl chloride; 2-Cyanopyridine-3-sulfonyl chloride; 3-(Chlorosulfonyl)picolinonitrile; 2-Cyanopyridine-3-sulfonic acid chloride; Picolinonitrile-3-sulfonyl chloride; 1060801-06-0; 2-Cyano-pyridine-3-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Cyanopyridine-3-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.