Description

2-Methyl-2-Propanyl (3R)-4-Iodo-3-({[(2-Methyl-2-Propanyl)Oxy]Carbonyl}Amino)Butanoate is a high-value, optically active iodo-amino acid derivative protected with tert-butyloxycarbonyl (Boc) and tert-butyl ester groups. This compound is a critical chiral building block in modern organic synthesis, prized for its role in constructing complex, stereodefined molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptidomimetics, protease inhibitors, and other bioactive molecules requiring a stereospecific iodo-substituted amino acid backbone.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators where specific stereochemistry influences biological activity.
• Peptide Chemistry: Serves as a protected, iodinated amino acid derivative for solid-phase and solution-phase peptide synthesis, enabling site-specific modifications.
• Chemical Biology Probes: Employed in the creation of labeled compounds and molecular probes for studying enzyme mechanisms and protein interactions.
• Cross-Coupling Reactions: The iodine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex carbon chains.
• Asymmetric Synthesis: Acts as a starting material or intermediate in multi-step asymmetric syntheses to install chiral centers with high enantiomeric purity.

Basic Information

Product Name	2-Methyl-2-Propanyl (3R)-4-Iodo-3-({[(2-Methyl-2-Propanyl)Oxy]Carbonyl}Amino)Butanoate
CAS No.	1059704-55-0
Molecular Formula	C14H24INO4
Molecular Weight	397.25 g/mol
Synonyms	(3R)-4-Iodo-3-({[(2-Methyl-2-Propanyl)Oxy]Carbonyl}Amino)Butanoic Acid 2-Methyl-2-Propanyl Ester; (R)-3-((tert-Butoxycarbonyl)amino)-4-iodobutanoic Acid tert-Butyl Ester; Boc-(R)-3-Amino-4-iodo-butanoic Acid t-Butyl Ester; tert-Butyl (R)-3-((tert-butoxycarbonyl)amino)-4-iodobutanoate; (R)-Boc-Abu(4-I)-OtBu; 1059704-55-0
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess, and impurity profile is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.