Description

tert-Butyl 2,4-Bis(Hydroxymethyl)Pyrrolidine-1-Carboxylate is a high-purity, protected pyrrolidine derivative that serves as a versatile and critical building block in advanced organic synthesis. Its bifunctional hydroxymethyl groups and protected amine make it an essential intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the production of advanced, chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioactive Molecule Construction: The pyrrolidine scaffold is integral to designing peptidomimetics and other bioactive compounds that mimic natural peptides.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke, multi-step synthesis projects on behalf of clients.
• Academic and Industrial Research: A valuable reagent for methodological development in organic chemistry laboratories exploring new synthetic pathways.

Basic Information

Product Name	tert-Butyl 2,4-Bis(Hydroxymethyl)Pyrrolidine-1-Carboxylate
CAS No.	1058737-58-8
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	1-Boc-2,4-bis(hydroxymethyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-2,4-bis(hydroxymethyl)pyrrolidine; tert-Butyl 2,4-bis(hydroxymethyl)-1-pyrrolidinecarboxylate; 2,4-Bis(hydroxymethyl)-1-pyrrolidinecarboxylic acid tert-butyl ester; 1-N-Boc-2,4-bis(hydroxymethyl)pyrrolidine; Pyrrolidine-1-carboxylic acid, 2,4-bis(hydroxymethyl)-, 1,1-dimethylethyl ester; Boc-2,4-bis(HM)Pyrrolidine
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 2,4-Bis(Hydroxymethyl)Pyrrolidine-1-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to meet the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.