Description

(1-(((Benzyloxy)Carbonyl)Amino)Cyclopropyl)Methyl Methanesulfonate is a high-purity, advanced pharmaceutical intermediate featuring a cyclopropane ring and a methanesulfonate (mesylate) ester group. This compound is of critical importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry and process development. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in multi-step organic synthesis for the development of novel Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the cyclopropyl and protected amino functionalities.
• Process Chemistry & Scale-Up: Employed in route scouting and kilogram-scale production for clinical trial material (CTM) manufacturing.
• Protease Inhibitor Synthesis: A key building block in the synthesis of compounds targeting viral proteases (e.g., HCV, HIV) and other enzyme targets.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules under cGMP or non-GMP conditions as required.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and bioorganic chemistry.

Basic Information

Product Name	(1-(((Benzyloxy)Carbonyl)Amino)Cyclopropyl)Methyl Methanesulfonate
CAS No.	1058137-81-7
Molecular Formula	C14H19NO5S
Molecular Weight	313.37 g/mol
Synonyms	[1-[[(Benzyloxy)carbonyl]amino]cyclopropyl]methyl methanesulfonate; N-[(1-[[(Benzyloxy)carbonyl]amino]cyclopropyl)methyl]methanesulfonamide (related form); Cbz-Protected Cyclopropylamine Mesylate Ester; (1-(Cbz-Amino)cyclopropyl)methyl Methanesulfonate; Z-ACPM Mesylate; Carbobenzoxy-ACPM Mesylate; (1-(((Benzyloxy)Carbonyl)Amino)Cyclopropyl)Methyl Mesylate
EINECS	Contact for details

Quality Control

Our (1-(((Benzyloxy)Carbonyl)Amino)Cyclopropyl)Methyl Methanesulfonate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with client requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.