Description

(R)-6-(3-Methylpiperazin-1-Yl)Nicotinonitrile is a high-purity chiral intermediate featuring a substituted piperazine ring linked to a cyanopyridine core. This compound matters as a critical building block in the synthesis of targeted pharmaceuticals, particularly for its role in constructing molecules with specific stereochemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), especially within therapeutic areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates.
• API Synthesis: Used in the multi-step synthesis of complex active pharmaceutical ingredients requiring specific (R)-stereochemistry.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Preclinical Development: Supplied for scale-up studies and the production of batches for toxicological and pharmacological testing.
• Contract Manufacturing: Utilized by CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Item	Details
Product Name	(R)-6-(3-Methylpiperazin-1-Yl)Nicotinonitrile
CAS No.	1057682-05-9
Molecular Formula	C11H14N4
Molecular Weight	202.26 g/mol
Synonyms	(R)-6-(3-Methyl-1-piperazinyl)-3-pyridinecarbonitrile; (R)-6-(3-Methylpiperazin-1-yl)nicotinonitrile; (R)-6-(3-Methylpiperazin-1-yl)pyridine-3-carbonitrile; (R)-3-Cyano-6-(3-methylpiperazin-1-yl)pyridine; (R)-6-(3-Methylpiperazinyl)nicotinonitrile; (R)-6-(3-Methylpiperazin-1-yl)-3-cyanopyridine; (R)-enantiomer of 6-(3-Methylpiperazin-1-yl)nicotinonitrile
EINECS	Contact for details

Quality Control

Our (R)-6-(3-Methylpiperazin-1-Yl)Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development and commercial projects with material suitable for research use or produced under current Good Manufacturing Practice (cGMP) guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.