Description

(S)-6-(3-Methylpiperazin-1-Yl)Nicotinonitrile is a high-purity chiral intermediate featuring a substituted piperazine ring linked to a cyano-pyridine core. This compound matters as a critical building block in the synthesis of targeted pharmaceuticals, enabling the development of novel therapeutic agents with specific stereochemistry. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors, particularly those focused on kinase inhibitors, central nervous system (CNS) agents, and other small-molecule drug discovery programs.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of new chemical entities (NCEs), especially for kinase-targeted therapies.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Preclinical Development: Serves as a critical starting material for scaling up candidate drugs under Good Laboratory Practice (GLP) conditions.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CRMOs) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for studying biochemical pathways and receptor interactions.
• Process Chemistry: Employed in developing and optimizing robust, scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(S)-6-(3-Methylpiperazin-1-Yl)Nicotinonitrile
CAS No.	1057682-03-7
Molecular Formula	C11H13N5
Molecular Weight	215.25 g/mol
Synonyms	(S)-6-(3-Methyl-1-piperazinyl)-3-pyridinecarbonitrile; (S)-3-Methyl-1-(5-cyano-2-pyridinyl)piperazine; (S)-6-(3-Methylpiperazin-1-yl)nicotinonitrile; 2-Pyridinecarbonitrile, 6-[(3S)-3-methyl-1-piperazinyl]-; (S)-6-(3-Methylpiperazin-1-yl)pyridine-3-carbonitrile; (S)-6-(3-Methylpiperazinyl)nicotinonitrile; (S)-6-(3-Methylpiperazin-1-yl)-3-cyanopyridine
EINECS	Contact for details

Quality Control

Our (S)-6-(3-Methylpiperazin-1-Yl)Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.