Description

2,3,5-Trifluoro-4-Iodopyridine is a high-value, multi-functional halogenated pyridine derivative. This compound serves as a critical building block in advanced organic synthesis, prized for its unique reactivity profile that enables the introduction of both fluorine and iodine substituents. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for CNS and oncology targets.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science: Serves as a monomer or functionalization agent for creating specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for Suzuki, Stille, and Sonogashira cross-coupling reactions to form complex biaryl systems.
• Fluorination Reagent Development: Acts as a starting material for synthesizing novel fluorinating agents or ligands for catalysis.
• Diagnostic Agent Research: Potential use in developing radiolabeled (e.g., with I-125) compounds for imaging and diagnostic applications.

Basic Information

Product Name	2,3,5-Trifluoro-4-Iodopyridine
CAS No.	1057393-65-3
Molecular Formula	C5HF3IN
Molecular Weight	276.97 g/mol
Synonyms	4-Iodo-2,3,5-trifluoropyridine; 2,3,5-Trifluoro-4-iodopyridine; Pyridine, 4-iodo-2,3,5-trifluoro-; 4-Iodo-2,3,5-trifluoropyridine; 2,3,5-Trifluoro-4-iodo-pyridine
EINECS	Contact for details

Quality Control

Our 2,3,5-Trifluoro-4-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.