Description

2-Chloro-5-Fluoroisonicotinonitrile is a high-value fluorinated and chlorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique halogenated structure makes it an indispensable intermediate for creating complex molecules with tailored biological and physical properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine substituents enhance bioactivity and environmental stability.
• Material Science Precursor: Serves as a starting material for synthesizing specialized ligands, catalysts, and functionalized polymers used in electronic and optical materials.
• Chemical Research: A versatile reagent in academic and industrial R&D for heterocyclic chemistry, cross-coupling reactions, and nucleophilic substitution studies.

Basic Information

Product Name	2-Chloro-5-Fluoroisonicotinonitrile
CAS No.	1057319-20-6
Molecular Formula	C6H2ClFN2
Molecular Weight	156.55 g/mol
Synonyms	5-Fluoro-2-chloroisonicotinonitrile; 2-Chloro-5-fluoropyridine-4-carbonitrile; 4-Cyano-2-chloro-5-fluoropyridine; 2-Chloro-5-fluoro-4-pyridinecarbonitrile; Isonicotinonitrile, 2-chloro-5-fluoro-; 1057319-20-6
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoroisonicotinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, impurity profile, and physical characteristics.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.