Description

1,3-Bis[(T-Butyldimethylsilyloxy)Methyl]Benzene is a high-purity, protected diol derivative used as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a robust, orthogonal protecting group strategy for primary alcohols, enabling complex multi-step synthesis with high selectivity and yield. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of active pharmaceutical ingredients (APIs), complex natural products, and novel materials.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide & Oligonucleotide Synthesis: Used to protect sensitive hydroxyl groups during solid-phase and solution-phase synthesis.
• Natural Product Synthesis: Enables the construction of intricate molecular architectures found in natural products with multiple alcohol functionalities.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers with tailored properties.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and protecting group chemistry.
• Agrochemical Synthesis: Intermediate in the production of advanced, high-performance crop protection agents.

Basic Information

Product Name	1,3-Bis[(T-Butyldimethylsilyloxy)Methyl]Benzene
CAS No.	1055310-31-0
Molecular Formula	C20H38O2Si2
Molecular Weight	366.69 g/mol
Synonyms	1,3-Bis[(tert-Butyldimethylsilyloxy)methyl]benzene; 1,3-Bis((tert-butyldimethylsilyloxy)methyl)benzene; 1,3-Bis[(TBDMS-oxy)methyl]benzene; m-Xylene-α,α'-diol bis(TBDMS ether); 1,3-Bis(hydroxymethyl)benzene bis(tert-butyldimethylsilyl ether); m-Phthalaldehyde TBDMS acetal; TBDMS-protected m-Benzenedimethanol
EINECS	Contact for details

Quality Control

Our 1,3-Bis[(T-Butyldimethylsilyloxy)Methyl]Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.