Description

(3-Chloro-5-Trifluoromethyl-Pyridin-2-Yl)-Acetic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core with chloro and trifluoromethyl substituents. This compound is a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the agrochemical and pharmaceutical sectors where its unique halogenated structure imparts desirable biological activity and metabolic stability. It is essential for R&D chemists and process development teams in life sciences companies seeking to develop new crop protection agents or therapeutic molecules.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of modern herbicides and insecticides, leveraging the bioactivity of the chlorinated trifluoromethylpyridine moiety.
• Pharmaceutical Building Block: Used in medicinal chemistry for the research and development of new drug candidates, especially in areas requiring fluorinated compounds for enhanced potency and pharmacokinetics.
• Chemical Synthesis Reagent: Serves as a versatile ethyl ester derivative for further functionalization, including hydrolysis to the corresponding acid or amide coupling reactions.
• Material Science Research: Employed in the development of specialty chemicals and functional materials that incorporate fluorinated aromatic systems.

Basic Information

Product Name	(3-Chloro-5-Trifluoromethyl-Pyridin-2-Yl)-Acetic Acid Ethyl Ester
CAS No.	1053656-47-5
Molecular Formula	C10H9ClF3NO2
Molecular Weight	267.63 g/mol
Synonyms	Ethyl (3-chloro-5-(trifluoromethyl)pyridin-2-yl)acetate; 2-Pyridineacetic acid, 3-chloro-5-(trifluoromethyl)-, ethyl ester; Ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)acetate; (3-Chloro-5-trifluoromethyl-2-pyridyl)acetic acid ethyl ester; 1053656-47-5; Acetic acid, (3-chloro-5-(trifluoromethyl)-2-pyridinyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our production of (3-Chloro-5-Trifluoromethyl-Pyridin-2-Yl)-Acetic Acid Ethyl Ester adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.