Description

tert-Butyl 3-Hydroxy-3-(Trifluoromethyl)Piperidine-1-Carboxylate is a high-value, protected piperidine derivative featuring both a hydroxyl and a trifluoromethyl group on the same carbon, making it a versatile and sophisticated chiral building block. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers for creating novel active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) and metabolic disease therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for CNS-targeted therapies.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated active ingredients for crop protection products.
• Organofluorine Chemistry: Serves as a valuable precursor for introducing the trifluoromethyl group into more complex molecular architectures.
• Medicinal Chemistry SAR Studies: Employed to explore structure-activity relationships by modifying the piperidine scaffold.
• Peptidomimetics & Bioisosteres: The hydroxyl and trifluoromethyl motifs are used to design peptide mimics and bioisosteric replacements in drug design.
• Ligand & Catalyst Development: Potential use in developing chiral ligands and catalysts for asymmetric synthesis.

Basic Information

Product Name	tert-Butyl 3-Hydroxy-3-(Trifluoromethyl)Piperidine-1-Carboxylate
CAS No.	1052713-78-6
Molecular Formula	C11H18F3NO3
Molecular Weight	269.26 g/mol
Synonyms	1-Boc-3-Hydroxy-3-(trifluoromethyl)piperidine; 3-Hydroxy-3-(trifluoromethyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-hydroxy-3-(trifluoromethyl)piperidine; N-Boc-3-Hydroxy-3-trifluoromethylpiperidine; 3-Trifluoromethyl-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 3-Hydroxy-3-trifluoromethyl-piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Hydroxy-3-(Trifluoromethyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.