Description

Propargyl-Peg3-Phosphonic Acid Ethyl Ester is a specialized bifunctional chemical building block that combines a reactive propargyl group with a phosphonic acid ester moiety via a hydrophilic triethylene glycol (PEG3) spacer. This unique structure makes it a critical intermediate for the synthesis of complex molecules, particularly in the development of bioconjugates and advanced materials. It is essential for researchers and manufacturers in pharmaceutical development, biotech, and materials science who require precise, high-purity linkers for click chemistry, surface modification, and targeted drug delivery systems.

Application

• Bioconjugation and Click Chemistry: Serves as a key linker for attaching biomolecules (e.g., peptides, antibodies, oligonucleotides) to surfaces, nanoparticles, or other molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Pharmaceutical Research: Used in the synthesis of antibody-drug conjugates (ADCs), prodrugs, and targeted therapeutic agents where a hydrophilic spacer and stable phosphonate linkage are beneficial.
• Surface Functionalization: Enables the modification of materials (e.g., glass, metals, polymers) with alkyne groups for subsequent bio-immobilization or creating functional coatings.
• Materials Science: Acts as a monomer or cross-linker in the development of novel polymers, hydrogels, and smart materials with tailored properties.
• Diagnostic Reagents: Employed in the fabrication of biosensors, diagnostic assays, and imaging probes by linking targeting agents to signal-generating components.
• Chemical Biology Probes: Facilitates the creation of activity-based probes and affinity labels for studying enzyme function and protein interactions.

Basic Information

Product Name	Propargyl-Peg3-Phosphonic Acid Ethyl Ester
CAS No.	1052678-30-4
Molecular Formula	C13H25NO7P
Molecular Weight	338.32 g/mol
Synonyms	2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]ethylphosphonic Acid Ethyl Ester; Propargyl-PEG3-phosphonate; Ethyl 2-[2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy]ethylphosphonate; Propargyl-O-(CH2CH2O)3-CH2CH2-PO(OEt)OH; Alkyne-PEG3-phosphonic Acid Ethyl Ester; Propargyl PEG3 Phosphonate Ester; 2,5,8,11-Tetraoxatetradec-13-yn-14-ylphosphonic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Propargyl-Peg3-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.