Description

(R)-4-(Trifluoromethyl)Phenylalanine T-Butyl Ester is a high-value, non-natural amino acid derivative featuring a chiral center and a trifluoromethyl group. This compound is a critical chiral building block in modern pharmaceutical research and development, prized for its ability to impart metabolic stability and modulate the lipophilicity of peptide-based drug candidates. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs and small molecule APIs targeting metabolic diseases, CNS disorders, and oncology.
• Peptidomimetic Research: Used to incorporate the (R)-4-(trifluoromethyl)phenylalanine moiety into peptide backbones to enhance binding affinity, proteolytic stability, and membrane permeability.
• Asymmetric Synthesis: Serves as a versatile starting material or chiral auxiliary in asymmetric catalytic reactions and multi-step synthetic routes.
• Chemical Biology Probes: Employed in the development of labeled peptides and activity-based probes for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Potential intermediate in the discovery of novel herbicides or fungicides with improved efficacy and environmental profiles.

Basic Information

Product Name	(R)-4-(Trifluoromethyl)Phenylalanine T-Butyl Ester
CAS No.	1052168-10-1
Molecular Formula	C14H16F3NO2
Molecular Weight	287.28 g/mol
Synonyms	(R)-3-(4-(Trifluoromethyl)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid; (R)-2-((tert-Butoxycarbonyl)amino)-3-[4-(trifluoromethyl)phenyl]propanoic acid; Boc-(R)-4-CF3-Phe-OH; tert-Butyl (R)-2-amino-3-(4-(trifluoromethyl)phenyl)propanoate; (R)-N-Boc-4-(Trifluoromethyl)phenylalanine
EINECS	Contact for details

Quality Control

Our (R)-4-(Trifluoromethyl)Phenylalanine T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent hydrolysis of the ester moiety. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.