Description

1-Boc-4'-Oxo-Spiro[Piperidine-4,2'-Oxane[3,2-B]Py] (CAS 1051383-43-7) is a high-value, protected spirocyclic piperidine derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique molecular architecture, featuring a Boc-protected amine and a fused oxane-pyridine system, makes it indispensable for constructing complex nitrogen-containing heterocycles. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and for use in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Scaffold: Used to explore structure-activity relationships (SAR) due to its rigid, three-dimensional spirocyclic core.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Chemical Biology Probe Development: Utilized in the creation of molecular probes for studying biological pathways and protein-ligand interactions.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in heterocyclic and spiro compound synthesis.
• Custom Synthesis & Scale-Up: A starting material for custom manufacturing projects requiring multi-step synthesis of complex target molecules.

Basic Information

Product Name	1-Boc-4'-Oxo-Spiro[Piperidine-4,2'-Oxane[3,2-B]Py]
CAS No.	1051383-43-7
Molecular Formula	C17H25NO4
Molecular Weight	307.39 g/mol
Synonyms	1-Boc-4'-oxospiro[piperidine-4,2'-oxane[3,2-b]pyridine]; tert-Butyl 4'-oxospiro[piperidine-4,2'-oxane[3,2-b]pyridine]-1-carboxylate; 1-(tert-Butoxycarbonyl)-4'-oxospiro[piperidine-4,2'-oxane[3,2-b]pyridine]; Spiro[piperidine-4,2'-oxane[3,2-b]pyridin]-4'-one, 1-Boc-protected; 1-Boc-4'-oxo-spiro(piperidine-4,2'-[1,4]oxazino[2,3-b]pyridine); 1051383-43-7; Boc-protected spirocyclic ketone
EINECS	Contact for details

Quality Control

Our 1-Boc-4'-Oxo-Spiro[Piperidine-4,2'-Oxane[3,2-B]Py] is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with every batch and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.