Description

tert-Butyl 6-Nitro-4-Oxo-3,4-Dihydrospiro[1-Benzopyran-2,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and piperidine-based molecular architecture. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold in hit-to-lead and lead optimization programs to explore structure-activity relationships (SAR).
• Protease Inhibitor Development: The structural motifs present make it a candidate for the development of novel protease inhibitors.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by CDMOs for the contract manufacturing of bespoke compounds for client-specific drug discovery projects.
• Library Synthesis: Acts as a core structure for generating focused chemical libraries for high-throughput screening (HTS).

Basic Information

Product Name	tert-Butyl 6-Nitro-4-Oxo-3,4-Dihydrospiro[1-Benzopyran-2,4'-Piperidine]-1'-Carboxylate
CAS No.	1051383-05-1
Molecular Formula	C18H22N2O6
Molecular Weight	362.38 g/mol
Synonyms	1'-Boc-6-nitro-4-oxo-3,4-dihydrospiro[chromene-2,4'-piperidine]; tert-Butyl 6-nitro-4-oxospiro[chromene-2,4'-piperidine]-1'-carboxylate; 6-Nitro-4-oxo-3,4-dihydrospiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[chromene-2,4'-piperidine]-1'-carboxylic acid, 6-nitro-4-oxo-3,4-dihydro-, 1,1-dimethylethyl ester; 1051383-05-1; Boc-6-nitro-4-oxo-spiro[chromene-2,4'-piperidine]; tert-Butyl 6-nitro-4-oxo-3,4-dihydro-2H-spiro[chromene-2,4'-piperidine]-1'-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Nitro-4-Oxo-3,4-Dihydrospiro[1-Benzopyran-2,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for each lot, and we support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.