Description

(+/-)-trans-4-(4-Pyridinyl)Pyrrolidine-3-Carboxylic Acid Dihydrochloride is a high-purity, non-natural amino acid derivative and a key chiral building block in advanced organic synthesis. This compound is valued for its rigid, bicyclic scaffold and dual functional groups, which are essential for constructing complex molecular architectures with precise stereochemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and specialized ligands for medicinal chemistry and chemical biology applications.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease therapeutic areas.
• Peptidomimetic Scaffold: Serves as a constrained proline analog for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Ligand Synthesis: Used in the preparation of specialized chelating agents and catalysts for asymmetric synthesis and metal-organic frameworks (MOFs).
• Chemical Biology Probe Development: Employed as a building block for creating molecular probes to study enzyme function and protein-protein interactions.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic chemistry, including novel cyclization and cross-coupling reactions.

Basic Information

Product Name	(+/-)-trans-4-(4-Pyridinyl)Pyrrolidine-3-Carboxylic Acid Dihydrochloride
CAS No.	1049740-23-9
Molecular Formula	C10H13N3O2 • 2HCl
Molecular Weight	280.15 g/mol (Free base: 207.23 g/mol)
Synonyms	trans-4-(4-Pyridyl)-3-pyrrolidinecarboxylic acid dihydrochloride; 4-(Pyridin-4-yl)-L-proline dihydrochloride (racemic trans isomer); 3-Carboxy-4-(4-pyridyl)pyrrolidine dihydrochloride; 4-(4-Pyridinyl)-3-pyrrolidinecarboxylic acid dihydrochloride; Pyrrolidine-3-carboxylic acid, 4-(4-pyridinyl)-, hydrochloride (1:2), trans-; (3R,4S)- and (3S,4R)-4-(Pyridin-4-yl)pyrrolidine-3-carboxylic acid dihydrochloride
EINECS	Contact for details

Quality Control

Our (+/-)-trans-4-(4-Pyridinyl)Pyrrolidine-3-Carboxylic Acid Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for isomeric composition, and NMR for structural confirmation, to ensure it meets the stringent requirements for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99:1 trans/cis isomeric ratio
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.