Description

(+/-)-trans-4-(6-Methoxy-3-Pyridinyl)Pyrrolidine-3-Carboxylic Acid Dihydrochloride CAS NO 1049740-13-7 is a high-purity, non-racemic chiral building block and pharmaceutical intermediate. This compound is of significant value for its role in the synthesis of complex molecules, particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in drug discovery programs targeting neurological and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a constrained scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Neurological Drug Discovery: Serves as a precursor in the synthesis of potential ligands for central nervous system (CNS) targets.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and protein function.
• Process Chemistry Development: Employed in route scouting and optimization for scalable API manufacturing.
• Academic Research: Used in university and institutional labs for synthetic organic chemistry and pharmacology projects.

Basic Information

Product Name	(+/-)-trans-4-(6-Methoxy-3-Pyridinyl)Pyrrolidine-3-Carboxylic Acid Dihydrochloride
CAS No.	1049740-13-7
Molecular Formula	C12H16N2O3 · 2HCl
Molecular Weight	309.19 g/mol (Free base: 236.27 g/mol)
Synonyms	trans-4-(6-Methoxypyridin-3-yl)pyrrolidine-3-carboxylic acid dihydrochloride; 4-(6-Methoxy-3-pyridinyl)-3-pyrrolidinecarboxylic acid dihydrochloride, trans-(±)-; 3-Pyrrolidinecarboxylic acid, 4-(6-methoxy-3-pyridinyl)-, dihydrochloride, trans-(±)-; (3R,4S) and (3S,4R)-4-(6-Methoxy-3-pyridinyl)pyrrolidine-3-carboxylic acid dihydrochloride; 1049740-13-7; (RS)-trans-4-(6-Methoxy-3-pyridinyl)pyrrolidine-3-carboxylic acid dihydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material suitable for research and development use, with typical purity exceeding 97% (HPLC). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality system is designed to support GMP-grade production upon demand.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and opened in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.