Description

(+/-)-trans-4-(3-Pyridinyl)Pyrrolidine-3-Carboxylic Acid Dihydrochloride is a high-purity, pharmaceutically relevant chiral building block and intermediate. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting neurological and metabolic disorders. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of potential therapeutic agents, including nicotinic acetylcholine receptor (nAChR) modulators.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probe Development: Used in the design and creation of molecular probes to study biological pathways and protein-ligand interactions.
• Academic Research: Employed in university and institutional labs for synthetic organic chemistry and pharmacology studies.
• Process Chemistry Development: Utilized in scaling up synthetic routes from milligram to kilogram scale for preclinical and clinical trial material supply.

Basic Information

Product Name	(+/-)-trans-4-(3-Pyridinyl)Pyrrolidine-3-Carboxylic Acid Dihydrochloride
CAS No.	1049739-96-9
Molecular Formula	C10H14N2O2 • 2HCl
Molecular Weight	279.16 g/mol
Synonyms	(±)-trans-4-(3-Pyridyl)pyrrolidine-3-carboxylic acid dihydrochloride; trans-4-(Pyridin-3-yl)pyrrolidine-3-carboxylic acid dihydrochloride (racemic); 3-Pyridinepropanamine, γ-amino-β-carboxy-, pyrrolidine deriv., dihydrochloride; 4-(3-Pyridinyl)-3-pyrrolidinecarboxylic Acid Dihydrochloride, trans-(±)-; 3-Carboxy-4-(3-pyridyl)pyrrolidine Dihydrochloride; rac-trans-4-(3-Pyridinyl)pyrrolidine-3-carboxylic acid dihydrochloride; (RS)-trans-4-(3-Pyridinyl)pyrrolidine-3-carboxylic acid dihydrochloride
EINECS	Contact for details

Quality Control

Our (+/-)-trans-4-(3-Pyridinyl)Pyrrolidine-3-Carboxylic Acid Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.