Description

(R)-α-(2-Pyridinylmethyl)-Pro2Hcl is a chiral, non-natural amino acid derivative characterized by a pyridinylmethyl side chain. This compound is a valuable chiral building block and intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating novel active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Peptidomimetic Synthesis: Used to incorporate non-natural amino acid motifs into peptides to enhance stability, bioavailability, and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Research: Employed in the study of enzyme mechanisms and protein-protein interactions as a probe or inhibitor scaffold.
• Fine Chemical Production: An intermediate in the multi-step synthesis of specialty chemicals and advanced materials.

Basic Information

Product Name	(R)-α-(2-Pyridinylmethyl)-Pro2Hcl
CAS No.	1049732-38-8
Molecular Formula	C14H21ClN2O2
Molecular Weight	284.78 g/mol
Synonyms	(R)-2-((Pyridin-2-yl)methyl)pyrrolidine-2-carboxylic acid hydrochloride; (R)-α-(2-Pyridylmethyl)proline hydrochloride; (R)-2-(2-Pyridinylmethyl)-1-pyrrolidinecarboxylic acid hydrochloride; (R)-2-((2-Pyridinyl)methyl)proline HCl; (R)-Pyridylmethylproline HCl; (R)-PMP-HCl; (R)-2-Pyridylmethylproline hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-α-(2-Pyridinylmethyl)-Pro2Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.