Description

3-Cyano-2,6-Dihydroxy-4-(Trifluoromethyl)Pyridine Dihydrate is a high-value pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethyl and cyano functional groups make it an essential precursor for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials and metal-organic frameworks (MOFs) due to its rigid, functionalized structure.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoromethyl group into complex molecules, a common strategy in modern medicinal and agrochemistry.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	3-Cyano-2,6-Dihydroxy-4-(Trifluoromethyl)Pyridine Dihydrate
CAS No.	1049729-56-7
Molecular Formula	C7H3F3N2O2 · 2H2O
Molecular Weight	232.13 g/mol (Anhydrous basis: 196.11 g/mol)
Synonyms	4-(Trifluoromethyl)-2,6-dihydroxynicotinonitrile Dihydrate; 2,6-Dihydroxy-4-(trifluoromethyl)-3-pyridinecarbonitrile Dihydrate; 3-Pyridinecarbonitrile, 2,6-dihydroxy-4-(trifluoromethyl)-, Dihydrate; 3-Cyano-2,6-dihydroxy-4-trifluoromethylpyridine Dihydrate; 4-(Trifluoromethyl)-2,6-dihydroxypyridine-3-carbonitrile Dihydrate
EINECS	Contact for details

Quality Control

Every batch of 3-Cyano-2,6-Dihydroxy-4-(Trifluoromethyl)Pyridine Dihydrate is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality protocols are designed to meet the stringent standards required for pharmaceutical and agrochemical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	13.0 - 16.0% (Theoretical for Dihydrate: ~15.5%)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.