Description

2-Amino-5-Bromo-3-Fluoro-Benzoic Acid Methyl Ester is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. This compound matters as a critical intermediate for constructing complex molecules, offering versatile reactivity through its amine, bromo, fluoro, and ester functional groups. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and stability.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its halogenated aromatic structure.
• Chemical Biology & Proteomics: Employed as a derivatization agent or a scaffold for designing molecular probes and enzyme inhibitors.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Amino-5-Bromo-3-Fluoro-Benzoic Acid Methyl Ester
CAS No.	1049106-42-4
Molecular Formula	C8H7BrFNO2
Molecular Weight	248.05 g/mol
Synonyms	Methyl 2-Amino-5-Bromo-3-Fluorobenzoate; 5-Bromo-3-Fluoro-2-Aminobenzoic Acid Methyl Ester; Benzoic acid, 2-amino-5-bromo-3-fluoro-, methyl ester; 2-Amino-5-bromo-3-fluorobenzoic acid methyl ester; Methyl 5-bromo-3-fluoro-2-aminobenzoate; 1049106-42-4; 2-Amino-5-bromo-3-fluoro-benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Bromo-3-Fluoro-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.