Description

3-Ethynyl-5-(Trifluoromethyl)-2-Pyridinylamine is a high-value, multi-functional pyridine derivative featuring both an ethynyl group and a trifluoromethyl substituent, making it a versatile and potent building block in advanced chemical synthesis. Its unique structure provides significant advantages in modulating the electronic properties, metabolic stability, and binding affinity of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated ethynyl moiety.
• Ligand and Catalyst Development: Employed in organometallic chemistry and catalysis research to create novel ligands for transition metal complexes.
• Fluorine Chemistry Research: An important compound for studying structure-activity relationships (SAR) in medicinal and agrochemical chemistry, leveraging the properties of the CF3 group.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized pyridine derivatives.

Basic Information

Product Name	3-Ethynyl-5-(Trifluoromethyl)-2-Pyridinylamine
CAS No.	1048914-02-8
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	3-Ethynyl-5-(trifluoromethyl)pyridin-2-amine; 2-Amino-3-ethynyl-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-3-ethynylpyridin-2-amine; 3-Ethynyl-5-trifluoromethyl-2-pyridinamine; 3-Ethynyl-5-trifluoromethylpyridin-2-ylamine; 2-Pyridinamine, 3-ethynyl-5-(trifluoromethyl)-; 1048914-02-8
EINECS	Contact for details

Quality Control

Our 3-Ethynyl-5-(Trifluoromethyl)-2-Pyridinylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.