Description

Ethyl 3-Bromo-5-(Trifluoromethyl)-2-Pyridinecarboxylate is a high-value pyridine derivative and versatile chemical building block, essential for advanced organic synthesis. Its molecular structure, featuring both bromo and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialized ligands, organic semiconductors, and liquid crystal materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form complex biaryl structures.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Ethyl 3-Bromo-5-(Trifluoromethyl)-2-Pyridinecarboxylate
CAS No.	1048384-90-2
Molecular Formula	C9H7BrF3NO2
Molecular Weight	298.06 g/mol
Synonyms	3-Bromo-5-(trifluoromethyl)picolinic acid ethyl ester; Ethyl 3-bromo-5-(trifluoromethyl)picolinate; 2-Pyridinecarboxylic acid, 3-bromo-5-(trifluoromethyl)-, ethyl ester; Ethyl 3-bromo-5-trifluoromethylpyridine-2-carboxylate; 3-Bromo-5-trifluoromethyl-pyridine-2-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 3-Bromo-5-(Trifluoromethyl)-2-Pyridinecarboxylate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for research and scale-up activities. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and GC-MS is supplied with each shipment to guarantee traceability and consistency for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.