Description

1-Methylspiro[Indole-3,4′-Piperidin]-2(1H)-One Hydrochloride is a high-purity, complex heterocyclic compound offered as a hydrochloride salt for enhanced stability and handling. This advanced pharmaceutical intermediate is critical for research and development in medicinal chemistry, particularly for targeting central nervous system (CNS) receptors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of potential new chemical entities (NCEs) for drug discovery programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop compounds with optimized biological activity and pharmacokinetic profiles.
• Neuroscience & CNS Drug Development: Serves as a core scaffold for investigating ligands that interact with specific neural receptors and enzymes.
• Reference Standard: Employed as an analytical standard in quality control and method development for related pharmaceutical compounds.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing specialized synthetic and development services to the biopharma industry.

Basic Information

Product Name	1-Methylspiro[Indole-3,4′-Piperidin]-2(1H)-One Hydrochloride
CAS No.	1047657-65-7
Molecular Formula	C14H17ClN2O
Molecular Weight	264.75 g/mol
Synonyms	1-Methylspiro[indole-3,4'-piperidin]-2(1H)-one hydrochloride; 1-Methyl-2-oxospiro[indole-3,4'-piperidine] hydrochloride; 1-Methylspiro[indoline-3,4'-piperidin]-2-one hydrochloride; 1047657-65-7; Spiro[indole-3,4'-piperidine]-2(1H)-one, 1-methyl-, hydrochloride; 1-Methyl-1'H-spiro[indole-3,4'-piperidin]-2-one hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Methylspiro[Indole-3,4′-Piperidin]-2(1H)-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.