Description

Spiro[Chroman-2,3'-Pyrrolidin]-4-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic molecular architecture. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged spiro scaffold.
• Preclinical Development: Serves as a critical material for producing batches required for pharmacological and toxicological evaluation.
• Academic Research: Employed in university and institutional labs for studying novel heterocyclic chemistry and bioorganic synthesis pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	Spiro[Chroman-2,3'-Pyrrolidin]-4-One Hydrochloride
CAS No.	1047655-65-1
Molecular Formula	C15H18ClNO2
Molecular Weight	279.76 g/mol
Synonyms	Spiro[chroman-2,3'-pyrrolidin]-4-one, hydrochloride; 4-Oxospiro[chroman-2,3'-pyrrolidine] hydrochloride; 1'-Azaspiro[chroman-2,3'-pyrrolidin]-4-one hydrochloride; 1047655-65-1; Spirochromane-pyrrolidinone HCl; Spirocyclic chromanone hydrochloride
EINECS	Contact for details

Quality Control

Our Spiro[Chroman-2,3'-Pyrrolidin]-4-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, ensuring compliance with the stringent requirements of pharmaceutical R&D and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.