Description

6-Acetylenylpyridyl-3-Aldehyde is a high-purity, functionalized pyridine derivative characterized by its reactive aldehyde and terminal alkyne groups. This unique bifunctional structure makes it a versatile and valuable building block for advanced organic synthesis and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Serves as a scaffold for creating novel ligands for transition metal catalysis and organocatalysts.
• Click Chemistry: The terminal alkyne group enables efficient Huisgen cycloaddition (click chemistry) for bioconjugation and polymer functionalization.
• Material Science: Building block for organic semiconductors, metal-organic frameworks (MOFs), and functional polymers.
• Chemical Biology Probes: Used to create molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	6-Acetylenylpyridyl-3-Aldehyde
CAS No.	1047627-04-2
Molecular Formula	C8H5NO
Molecular Weight	131.13 g/mol
Synonyms	3-Formyl-6-ethynylpyridine; 6-Ethynylpyridine-3-carboxaldehyde; 6-Ethynyl-3-pyridinecarboxaldehyde; 3-Pyridinecarboxaldehyde, 6-ethynyl-; 6-Ethynylnicotinaldehyde; 6-Ethynyl-3-formylpyridine; 6-Acetylenyl-3-pyridinecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 6-Acetylenylpyridyl-3-Aldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, meeting the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive. Allow the container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.