Description

4-(5-Fluoropyridin-2-Yl)Benzonitrile is a high-value aromatic nitrile and fluoropyridine hybrid compound, serving as a critical advanced intermediate in modern synthetic chemistry. Its molecular architecture, featuring both a nitrile and a fluorinated heterocycle, makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluoropyridine moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Synthesis: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science: Employed in the research of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated system.
• Chemical Biology Probe Development: Utilized as a scaffold for creating molecular probes to study biological processes and enzyme functions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated nitrile structure.

Basic Information

Product Name	4-(5-Fluoropyridin-2-Yl)Benzonitrile
CAS No.	1046789-38-1
Molecular Formula	C₁₂H₇FN₂
Molecular Weight	198.20 g/mol
Synonyms	2-(4-Cyanophenyl)-5-fluoropyridine; 5-Fluoro-2-(4-cyanophenyl)pyridine; 4-(5-Fluoropyridin-2-yl)benzonitrile; [1,1'-Biphenyl]-4-carbonitrile, 2'-fluoro-; 2'-Fluoro[1,1'-biphenyl]-4-carbonitrile; 4-(5-Fluoro-2-pyridinyl)benzonitrile; Benzonitrile, 4-(5-fluoro-2-pyridinyl)-
EINECS	Contact for details

Quality Control

Every batch of 4-(5-Fluoropyridin-2-Yl)Benzonitrile is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity confirmation (by NMR and IR), and levels of specific impurities. Our quality commitment supports compliance with relevant research and development guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.