Description

tert-Butyl 5-Methoxy-4-(Trimethylsilyl)Pyridin-3-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine core functionalized with methoxy, trimethylsilyl, and carbamate protecting groups. This compound is critical for enabling complex synthetic routes in medicinal chemistry, offering a versatile and protected scaffold for the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the discovery and development of new pesticides and herbicides, leveraging its functionalized heterocyclic structure.
• Organic Synthesis Reagent: Acts as a protected amine precursor in complex organic transformations, including cross-coupling reactions and nucleophilic substitutions.
• Material Science Precursor: Potential use in the synthesis of organic ligands for catalysts or functional materials due to the silicon-containing moiety.
• Academic & Contract Research: Essential for research laboratories in universities and CROs (Contract Research Organizations) exploring new chemical entities and reaction methodologies.

Basic Information

Product Name	tert-Butyl 5-Methoxy-4-(Trimethylsilyl)Pyridin-3-Ylcarbamate
CAS No.	1045858-18-1
Molecular Formula	C14H24N2O3Si
Molecular Weight	296.44 g/mol
Synonyms	3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methoxy-4-(trimethylsilyl)pyridine; tert-Butyl N-[5-methoxy-4-(trimethylsilyl)-3-pyridyl]carbamate; 5-Methoxy-4-(trimethylsilyl)pyridin-3-amine, N-BOC-protected; BOC-5-Methoxy-4-TMS-3-aminopyridine; 3-(Boc-amino)-5-methoxy-4-(trimethylsilyl)pyridine; 1045858-18-1; Pyridine-3-carbamic acid, 5-methoxy-4-(trimethylsilyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Methoxy-4-(Trimethylsilyl)Pyridin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.