Description

tert-Butyl 4-Chloro-5-Methoxypyridin-3-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyridine-based carbamate structure. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, particularly in oncology and CNS research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new therapeutic molecules.
• API Synthesis: Serves as a key precursor in the production of complex Active Pharmaceutical Ingredients (APIs) requiring a functionalized pyridine core.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	tert-Butyl 4-Chloro-5-Methoxypyridin-3-Ylcarbamate
CAS No.	1045858-17-0
Molecular Formula	C11H15ClN2O3
Molecular Weight	258.70 g/mol
Synonyms	tert-Butyl (4-chloro-5-methoxypyridin-3-yl)carbamate; 3-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-chloro-5-methoxypyridine; 4-Chloro-5-methoxy-3-pyridinylcarbamic acid 1,1-dimethylethyl ester; 4-Chloro-5-methoxypyridin-3-yl-carbamic acid tert-butyl ester; tert-Butyl N-(4-chloro-5-methoxypyridin-3-yl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Chloro-5-Methoxypyridin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.